Pharmaceutical compound.



' pounds which have UNITED STATES PATENT OFFICE.

eRArrN MARIA v01.- LINDEN, or BONN, ERNST "MnIssEN, or normNHoNNEr, NEAR BONN, AND AR'IUB s'rnAuss, or BARMEN, GERMANY, ASSIGNORS ro FARBEN- FABRIKEN VORM'. FBIEDR. BAYER TION OF GERMANY.

No Drawing.

Specification of Letters Patent. Application filed February 11, 1913. Serial No. 747,714.

Patented Sept. 9, 1913.

To all whom it may concern: Be it known that we, GRZFIN MARIA VON LINDEN, professorinBonn, ERNST MEISSEN, professor of medicine in Hohenhonnef, and ARTUR STRAUSS, doctor of medicine in Barmen, citizens of the German Empire, residing, respectively, in Bonn, Hohenhonnef, near Bonn, and Barmen, Germany, have invented new and useful Improvements in Pharmaceutical Compounds, of which the following is a specification.

We have found that lecithin compounds,

such as lecithin, jecorin, cuorin, kephalin can be combined with inor anic or organic copper compounds to comp ex copper comroved to be valuable remedies against in ectious diseases, especially against tuberculosis.

he process for producing the new compounds consists in reacting with the copper compounds upon sus nsions or solutions of lecithin or of its ana ogues, until the copper compounds used have disappeared.

In order to illustrate the new process more fully the following examples are given, the parts being by weight:

Example 1: 1 part of the dry copper salt 6 of cinnamic acid is triturated at a moderate temperature together with 2 parts of lecithin until the blue color of the copper salt has disappeared and a uniform li ht green paste is obtained, which is the comp ex com \und obtained from the cinnamate of co per and the lecithin. It is soluble with a lig t green coloration in etherand chloroform, insoluble in alcohol, and contains about 5.5 per cent. 0

' copper.

as an amorphous brownish-green mass, soluble in ether and olive oil*w1th a light green coloration and insoluble in alcohol. It contains about 6 per cent. of copper and 3 per cent. of phosphorus.

The product obtained from kephalin (ob,-

' tained from the brains of cows) and copper acetate is a greenish product containing 5.5-6 per cent. of co per. The complex copper compound obtained from jecorin (proneed from the liver of horse's) contains about 5.7 per cent. of copper and 2.1 per cent. of phosphorus.

We claim 1. The new complex copper compounds of lecithin compounds, which are greenish products, soluble in ether and in chloroform,- insoluble in alcohol, containing about from 5 to 6 per cent. of copper; and beingvaluable remedies against infectious dlseases, substantially as described.

2. The new complex cop er compound of lecithin, being a browms -green product soluble in ether and olive oil with a light green coloration, containing about 6 per cent.

of copper and 3 per cent. of phosphorus;

being a valuable remedy against infectious diseases, substantially as described.

In testimony whereof we havehereunto set our hands in the scribing witnesses.

GRiiFIN MARIA VON LINDEN. ERNST MEISSEN. ARTUR STRAUSS.

presence of the sub- Witnesses to signatures of Griifin Maria von Linden and Ernst Meissen:

LOUIS VANDonY, 'Bnssm F. DUNLAP. Witnesses to signature of Artur Strauss:

HELEN Norm, ALBERT NUFER. 

